ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES

Ricardo Soares Mota Silva; Márcia Cristina de Souza; Lilian Berlini; José Roberto da Silveira Maia; Renata Diniz; Nivaldo Lúcio Speziali; Onkar Dev Dhingra; Vanny Perpetua Ferraz

doi:10.18540/jcecvl2iss2pp001-017

Autores

Ricardo Soares Mota Silva Universidade Federal de Viçosa
Márcia Cristina de Souza Universidade Federal de Juiz de Fora
Lilian Berlini Universidade Federal de Viçosa
José Roberto da Silveira Maia Universidade Federal de Viçosa
Renata Diniz Universidade Federal de Juiz de Fora
Nivaldo Lúcio Speziali Universidade Federal de Minas Gerais
Onkar Dev Dhingra Universidade Federal de Viçosa
Vanny Perpetua Ferraz Universidade Federal de Minas Gerais

DOI:

https://doi.org/10.18540/jcecvl2iss2pp001-017

Palavras-chave:

Antimicrobial activity, Bis(pyrimidin-2-ylthio)alkanes, Oligomeric copper(II) complexes, Bactericide, Fungicide.

Resumo

A novel series of copper(II) derivatives of bis(pyrimidin-2-ylthio)- and bis(4,6-dimethylpyrimidin-2-ylthio)alkane of general formula [CuxCly(L)z]n {x = 1, y = 2, z = 1, L = ptm (1), pte (2), dptm (4), dpte (5), dpth (6); x = 2, y = 4, z = 3, L = pth (3) were tested for antimicrobial activity. These complexes were characterized by elemental analysis, infrared spectroscopy (IR) and gel permeation chromatography (GPC). Complex-4, 5 and 6 have the metal at the center of a square planar geometry and in complex-1, 2 and 3 the metal is at the center a square pyramidal geometry. The structure of complex-4, determined by X-ray diffraction analysis, shows this compound as an oligomer with one-dimensional chain in zigzag conformation. The high average molecular mass (Mw) of these copper(II) complexes confirms their oligomeric character. Although the free ligands were inactive agaisnt the microorganisms tested, the copper(II) derivatives showed good antifungal and antibacterial inhibition against C. albicans, C. tropicalis, S. aureus and E. coli, more effective than Nystatin and Norfloxacin.